Obesity Abstracts

Background: Colorectal cancer (CRC) is the fourth most common cancer in UK. Obesity is a major modifiable risk factor for CRC. The LEP gene encodes the leptin hormone which is a key regulator of body weight. LEP is overexpressed in the colorectal mucosa of patients with CRC and may contribute to the development and progression of CRC. This study investigated the effects of weight loss induced by bariatric surgery (BS) on LEP gene methylation in recta...